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Neanderthal DNA: What Genomes Tells Us About Their Sense of Smell

Following the scent behind Neanderthal DNA leads us to a better understanding of ancient humans. Explore recent breakthroughs in the Neanderthal genome and learn how researchers used smell tests to determine how our senses are similar.

Depiction of an ancient human walking in a cave.Credit: Gorodenkoff/Shutterstock

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Today, humans are the only members of our genus — the Homo from Homo sapiens — left alive. Remnants of our closest relatives, including Neanderthals and Denisovans, range from teeth and bones to tools and artwork, not to mention a genetic legacy in many modern humans thanks to interbreeding.

With a new study published in iScience, a group of researchers announced that ancient DNA has helped illuminate another aspect of our fellow humans’ lives: their sense of smell.

This research builds on previous studies, starting in 1997. A Swedish geneticist named Svante Pääbo and his colleagues published a paper, announcing that they had sequenced DNA from the 40,000-year-old arm bone of a Neanderthal.

Since then, Pääbo and his colleagues at the Max Planck Institute for Evolutionary Anthropology have gone on to publish entire Neanderthal and Denisovan genomes; he won the 2022 Nobel Prize in Physiology or Medicine.

“Without that lab, ...

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