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One Small Genetic Tweak May Stop Mosquitoes from Spreading Malaria

Mosquitoes can spread a deadly parasite that causes malaria. Learn how experts are using CRISPR to change the mosquito’s genome to stop this spread.

ByAvery Hurt
Malaria infected mosquito
Image Credit: nechaevkon/Shutterstock  

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What animal kills more humans than any other? The answer is not rhinos, or tigers, or even sharks. The answer is the tiny mosquito, vector for the Plasmodium parasite that causes malaria.

Each year more than 600,000 people die from the mosquito-borne illness, despite interventions, including the use of insecticide sprays, vaccines, and insecticide-treated bed nets, that have reduced deaths from malaria by 50 percent in the last decade.

Unfortunately, mosquitos are developing resistance to insecticides, and drug-resistant parasites are emerging, threatening to reverse this recent progress.

Now, however, a team of researchers at University of California, San Diego, University of São Paulo, Johns Hopkins University, and University of California, Berkeley, have discovered a potential new tool in the fight against malaria. The results were described in a paper published last month in the journal Nature.

By changing a single amino acid in the mosquito’s genome, researchers created a mosquito ...

  • Avery Hurt

    Avery Hurt is a freelance science journalist. In addition to writing for Discover, she writes regularly for a variety of outlets, both print and online, including National Geographic, Science News Explores, Medscape, and WebMD. She’s the author of Bullet With Your Name on It: What You Will Probably Die From and What You Can Do About It, Clerisy Press 2007, as well as several books for young readers. Avery got her start in journalism while attending university, writing for the school newspaper and editing the student non-fiction magazine. Though she writes about all areas of science, she is particularly interested in neuroscience, the science of consciousness, and AI–interests she developed while earning a degree in philosophy.

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