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Ancient Humans May Have Built a Resistance to Malaria

A mutation in DNA against malaria likely occurred when farming became common in the Eastern Arabia region.

ByElizabeth Gamillo
(Credit: Sirinn3249/Shutterstock)

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A mosquito-borne parasite, Plasmodium malariae causes malaria — a disease responsible for at least 608,000 deaths and 249 million cases in 2022, according to the World Health Organization. Malaria usually causes severe headaches, fevers, and chills for modern day humans.

But according to a new study, ancient humans in the modern-day Arabian Peninsula may have been resistant to the disease. A mutation in DNA most likely happened 5,000 years to 6,000 years ago, or when farming started in Eastern Arabia.

“This knowledge goes beyond historical understanding, providing predictive capabilities for disease susceptibility, spread, and treatment, thus promoting better health outcomes,” said Marc Haber, a geneticist at the University of Birmingham and one of the study authors, in a statement.

Arabia’s scorching and humid climate usually does not preserve ancient remains, meaning this new study is the first time that researchers have been able to analyze the ancient DNA from this ...

  • Elizabeth Gamillo

    Elizabeth Gamillo is a staff writer for Discover and Astronomy. She has written for Science magazine as their 2018 AAAS Diverse Voices in Science Journalism Intern and was a daily contributor for Smithsonian. She is a graduate student in MIT's Graduate Program in Science Writing.

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