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Are COVID-19 "Rebounds" Only Possible After Taking Paxlovid?

Antiviral treatments like Paxlovid reduce the severity of coronavirus symptoms, though they're also associated with mild resurgences of the disease. Why do these resurgences occur, and are they only possible after antiviral therapies?

BySam Walters
Credit: Cryptographer/Shutterstock

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The antiviral treatment Paxlovid arose as a common prescription among patients with COVID-19. But many recipients of the treatment reported that their coronavirus symptoms stopped suddenly, only to flare up again after a few days or weeks of reprieve. Known as "Paxlovid rebound," these flare-ups became a recurrent subject of study for infectious disease specialists.

But what do we really know about these rebounds? Why do they occur, and are they only possible among patients who have taken an antiviral treatment for COVID-19?

Paxlovid is an oral, antiviral treatment prescribed to patients in the initial stages of a COVID-19 infection who are already at an increased risk of developing severe symptoms of the disease. This pool of patients tends to include people who are older, unvaccinated and have certain medical conditions and concerns, such as asthma and cancer.

And according to scientists, its use among at-risk individuals is stunningly successful ...

  • Sam Walters

    Sam Walters is the associate editor at Discover Magazine who writes and edits articles covering topics like archaeology, paleontology, ecology, and evolution, and manages a few print magazine sections.

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