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The Little-Known Genetic Mutation Behind Many Aggressive Cancers

Despite the dangers of the KRAS-variant mutation, few doctors have heard of it. But one researcher is trying to change that.

Dr. Dynamo: Joanne Weidhaas’ boundless energy fuels her campaign to increase awareness of the KRAS-variant, a cancer-causing mutation she co-discovered. The many roles she plays — researcher, entrepreneur, marketer, evangelist — inspired this photo illustration, taken in her UCLA lab. Ian White

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Memorial Sloan Kettering Cancer Center, housed in magisterial granite and glass high-rises near New York City’s East River, is the court of last resort for the desperate and the dying. They often arrive in ambulances, accompanied by a filing cabinet full of medical records that recount in dispassionate detail years of ultimately futile therapies.

In the early 2000s, when Joanne Weidhaas was a radiation oncology resident at the renowned facility, one of her mentors made a chance remark that would shape the course of her career.

“Pay attention and notice this: You’ll see that cancer is not evenly spread,” he told her. “There will be people that get not just one, but two and even three different types of cancers.”

Weidhaas noticed. She saw the people hit again and again — in their lungs, then the colon or the pancreas. These patients haunted Weidhaas. “After their initial diagnosis, in the ...

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