The Little-Known Genetic Mutation Behind Many Aggressive Cancers

Despite the dangers of the KRAS-variant mutation, few doctors have heard of it. But one researcher is trying to change that.

By Linda Marsa
Oct 10, 2014 12:00 AMMay 21, 2019 5:30 PM
true-believer-cover
Dr. Dynamo: Joanne Weidhaas’ boundless energy fuels her campaign to increase awareness of the KRAS-variant, a cancer-causing mutation she co-discovered. The many roles she plays — researcher, entrepreneur, marketer, evangelist — inspired this photo illustration, taken in her UCLA lab. Ian White

Newsletter

Sign up for our email newsletter for the latest science news
 

Memorial Sloan Kettering Cancer Center, housed in magisterial granite and glass high-rises near New York City’s East River, is the court of last resort for the desperate and the dying. They often arrive in ambulances, accompanied by a filing cabinet full of medical records that recount in dispassionate detail years of ultimately futile therapies.

In the early 2000s, when Joanne Weidhaas was a radiation oncology resident at the renowned facility, one of her mentors made a chance remark that would shape the course of her career. 

“Pay attention and notice this: You’ll see that cancer is not evenly spread,” he told her. “There will be people that get not just one, but two and even three different types of cancers.”

Weidhaas noticed. She saw the people hit again and again — in their lungs, then the colon or the pancreas. These patients haunted Weidhaas. “After their initial diagnosis, in the back of your mind you’re always filled with this sickening dread because you’re wondering if they’ll have to go through this all over again,” she says. She also saw how unpredictably the disease struck. “Everyone thinks of cancer patients as old, sickly, 10-pack-a-day smokers, but many are super healthy. Cancer blindsides you — one day you’re healthy, and the next day you’re not.”

Biologist Frank Slack, now at Harvard, co-discovered the KRAS-variant with Weidhaas at Yale in 2008. The two continue to collaborate.Media Services/Beth Israel Deaconess Medical Center
0 free articles left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

0 free articlesSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!

Subscribe

Already a subscriber?

Register or Log In

Stay Curious

Sign up for our weekly newsletter and unlock one more article for free.

 

View our Privacy Policy


Want more?
Keep reading for as low as $1.99!


Log In or Register

Already a subscriber?
Find my Subscription

More From Discover
Recommendations From Our Store
Shop Now
Stay Curious
Join
Our List

Sign up for our weekly science updates.

 
Subscribe
To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2024 Kalmbach Media Co.