Dire Wolf De-Extinction Breeds Both Hope and Uncertainty

Follow the progress of Romulus, Remus, and Khaleesi, three wolves that have become the stars of Colossal Biosciences' dire wolf de-extinction project.

By Jack Knudson
Apr 8, 2025 10:40 PM
Dire Wolves Colossal Biosciences
Romulus and Remus (Images Courtesy of Colossal Biosciences)

Newsletter

Sign up for our email newsletter for the latest science news
 

The pursuit of de-extinction has broken new ground yet again, as three young wolves are carrying on the legacy of the dire wolf species that disappeared from Earth around 12,500 years ago. Dallas-based Colossal Biosciences, the company leading the de-extinction charge, recently declared that the dire wolf has returned for good.

The three wolves brought to life by the company — Romulus, Remus, and Khaleesi — emulate many unmistakable dire wolf characteristics, seen in their size, skull shape, and stunning white coats. This breakthrough was made possible with technology that allowed scientists to alter gray wolf genes so they would mirror extinct dire wolf genes; while serving as a stepping stone for future de-extinction endeavors, the dire wolf project may also pave the way for the future of conservation.

When Did Dire Wolves Live?

Romulus and Remus and puppies on the Iron Throne (Images Courtesy of Colossal Biosciences)

The dire wolf (Aenocyon dirus) once roamed throughout North and South America during the Late Pleistocene, facing extinction near the end of the last ice age. The species may have been doomed by its diet; it dined mostly on megaherbivores, many of which would vanish in the Americas starting around 13,000 years ago, leaving dire wolves with less prey to eat.

0 free articles left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

0 free articlesSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!

Subscribe

Already a subscriber?

Register or Log In

Stay Curious

Sign up for our weekly newsletter and unlock one more article for free.

 

View our Privacy Policy


Want more?
Keep reading for as low as $1.99!


Log In or Register

Already a subscriber?
Find my Subscription

More From Discover
Stay Curious
Join
Our List

Sign up for our weekly science updates.

 
Subscribe
To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2025 LabX Media Group