One small dose of a psychedelic compound could help brains better adapt to changing circumstances, potentially improving treatments for those struggling with depression, PTSD, and neurodegenerative diseases, according to experiments conducted in mice. The results of the study were reported in the journal Psychedelics.
"What makes this discovery particularly significant is the sustained duration of cognitive benefits following just one psychedelic dose," Omar J. Ahmed, a psychology researcher at the University of Michigan and a co-author of the study, said in a press release. "We observed enhanced learning adaptability that persisted for weeks, suggesting these compounds may induce lasting and behaviorally meaningful neuroplasticity changes in the prefrontal cortex."
Figure 1. Experimental timeline and overview. (A) Experimental timeline. (B) Schematic of the SEQFR2-forward protocol. Mice have to sequentially poke left and then right within 30 s to earn a reward pellet. (C) Schematic of the SEQFR2-reversal protocol. Mice now are required ...
