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Nicotine, the Wonder Drug?

This notorious stimulant may enhance learning and help treat Parkinson's, schizophrenia and other neurological diseases.

Nicotine delivery devices like the patch could offer surprising benefits to people diagnosed with certain neurological disorders.Credit: Cristina Pedrazzini/Science Photo Library

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Every drug of addiction must have its day. Morphine remains one of the most potent painkillers ever discovered. Cocaine’s chemical cousin lidocaine is still used by physicians and dentists as an effective local anesthetic. Even demon alcohol, when taken in moderation, cuts the risk of heart attacks, osteoporosis, rheumatoid arthritis and a hodgepodge of other ailments.

Now comes nicotine, perhaps the most unlikely wonder drug ever to be reviled.

If dozens of human and animal studies published over the past six years are borne out by large clinical trials, nicotine — freed at last of its noxious host, tobacco, and delivered instead by chewing gum or transdermal patch — may prove to be a weirdly, improbably effective drug for relieving or preventing a variety of neurological disorders, including Parkinson’s disease, mild cognitive impairment (MCI), Tourette’s and schizophrenia. It might even improve attention and focus enough to qualify as a cognitive ...

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