Register for an account

X

Enter your name and email address below.

Your email address is used to log in and will not be shared or sold. Read our privacy policy.

X

Website access code

Enter your access code into the form field below.

If you are a Zinio, Nook, Kindle, Apple, or Google Play subscriber, you can enter your website access code to gain subscriber access. Your website access code is located in the upper right corner of the Table of Contents page of your digital edition.

Health

Genetics + coffee = death...or...not

Gene ExpressionBy Razib KhanMarch 31, 2006 9:21 AM

Newsletter

Sign up for our email newsletter for the latest science news

Interesting paper out in JAMA, Coffee, CYP1A2 genotype, and risk of myocardial infarction:

The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers....Intake of coffee was associated with an increased risk of nonfatal MI only among individuals with slow caffeine metabolism, suggesting that caffeine plays a role in this association.

Imagine when insurance companies get their hands on this sort of information, they'll give you your lowest risk lifestyle dependent on your genotypic predispositions. This sort of trait indicates the contextual response of genes and subsequent development. Genes don't "determine" anything, they are important (or not) parameters in concert with a host of other variables. Here is a popular press review of this paper.

    2 Free Articles Left

    Want it all? Get unlimited access when you subscribe.

    Subscribe

    Already a subscriber? Register or Log In

    Want unlimited access?

    Subscribe today and save 70%

    Subscribe

    Already a subscriber? Register or Log In