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Alice In Wonderland Syndrome

Discover how Alice In Wonderland Syndrome can be triggered by topiramate, an anti-epileptic drug used for migraine prevention.

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One pill makes you largerAnd one pill makes you smallAnd the ones that mother gives youDon't do anything at allGo ask AliceWhen she's ten feet tall

So sang Jefferson Airplane in their psychedelic classic White Rabbit. While this song seems sure to have been inspired by the use of certain unapproved medications, don't have to be dropping acid to feel ten feet tall.

A new paper from Germany reports on a case of "Alice In Wonderland Syndrome" associated with topiramate, an anti-epileptic drug also used to prevent migraines:

A 17-year-old girl presented with a 7-year history of migraine... she was put on 50 mg topiramate at night... after 4 months the dose was further increased to 75 mg/day, as she was still having three to four headache days/month.

She then reported previously unknown intermittent nocturnal distortions of her body image only on those occasions when she did not directly fall ...

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