If knowing your enemy is half the battle, we may yet defeat the common cold. A paper published last April in
detailed how geneticists sequenced the RNA from 100 strains of rhinovirus—all the known types of the leading cause of the cold.
Pulmonologist Stephen Liggett of the University of Maryland School of Medicine says his team found regions of the genome that are similar across all strains. Those sequences, presumably essential to survival, are prime targets for new drugs. Equally notable are the bits of RNA that differ, which may explain why some bugs are nastier than others.
Rhinoviruses can instigate asthma or trigger severe wheezing episodes in asthmatics, but it is unclear whether only certain strains of the virus are to blame. Looking at large numbers of rhinovirus genomes may provide answers. “Just saying it’s rhinovirus is not sufficient, because there is so much diversity,” Liggett says.
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