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What's Up with Chronic Fatigue?

Chronic fatigue syndrome remains enigmatic, with studies linking XMRV retrovirus to CFS but results vary widely. Learn more about CFS.

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Here is some of the best drama you're going to see in science: two major studies are published six weeks apart and report exactly opposite results. Their subject? A squirrely syndrome that is anything from a devastating infectious disease to a made-up malaise, depending who you ask.

Chronic fatigue syndrome, or CFS, is (quick overview!) pretty much what it sounds like. Its trademark is a crippling exhaustion that lasts for months or years. There's no test or cure for CFS. Doctors first rule out every other possibility--such as hormonal problems, mental illnesses, sleep disorders, or lupus--before giving a diagnosis of CFS.

The syndrome jumped into headlines last year when Science published a paper announcing a correlation between CFS and a certain retrovirus called XMRV. A retrovirus is (quick overview!) a virus that cleverly inserts its own genes into your DNA, so your body keeps replicating it. HIV is one.

The ...

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