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What average genetic variation can tell us (or not)

Explore Bushmen genetic diversity and how it highlights the extensive genetic variation among African populations.

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To the left I've juxtaposed the images of the four Bushmen males whose genomes were analyzed in the recent Nature paper and compared to Desmond Tutu. I've added to the montage a photo of a Swedish and Chinese man. The Nature paper looked at the HapMap data sets which had within them whites from Utah, northwest Europeans, and Chinese from Beijing, and compared these populations to the Bushmen and Desmond Tutu. One important point that this paper emphasized was that the rule-of-thumb that African populations have the most extant genetic diversity of all human groups, and that the Bushmen have the most diversity of all (perhaps with the Pygmy groups of Central Africa), seems broadly confirmed:

In the 117 megabases (Mb) of sequenced exome-containing intervals, the average rate of nucleotide differences between a pair of the Bushmen was 1.2 per kilobase, compared to an average of 1.0 per kilobase differing ...

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