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Natural selection of a human gene: FUT2

Explore how natural selection signals are evident in FUT2 polymorphism and its implications for human genetic diversity.

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A few months ago I reviewed a paper which examined the various complexities of interpreting signals of natural selection from recently developed genomic tests in response to the avalanche of human sequence data. In the paper, Signals of recent positive selection in a worldwide sample of human populations, the authors state:

We find that putatively selected haplotypes tend to be shared among geographically close populations. In principle, this could be due to issues of statistical power: broad geographical groupings share a demographic history and thus have similar power profiles. However, strongly selected loci are expected to show geographical patterns largely independent of demography--depending on the relevant selection pressures, they can be highly geographically restricted despite moderate levels of migration, or spread rapidly throughout a species even in the presence of little migration...Further exploration of the geographic patterns in these data and their implications is warranted, but from the point of ...

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