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This Is Your Brain on Magic Mushrooms

Discover how psychedelic substances change mindset and uncover their impact on brain connectivity patterns with psilocybin insights.

Left, the stable brain activity in a normal brain. Right, under the influence of psilocybin, diverse brain regions not normally in communication become strongly linked.

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Psychedelic substances can change a user’s mindset in profound ways — a fact that’s relevant even to those who’ve never touched the stuff, because such altered states of consciousness give scientists a window into how our brains give rise to our normal mental states. But neuroscientists are only beginning to understand how and why those mental changes occur.

Now some mathematicians have jumped into the fray, using a new mathematical technique to analyze the brains of people on magic mushrooms.

Scientists have known for decades that many of psychedelic drugs’ most famous effects — visual hallucinations, heightened sensory and emotional sensitivity, etc. — are linked to elevated levels of the neurotransmitter serotonin.

But increasingly neuroscience researchers are interested not just in single chemicals but also in overall brain activity, because the most complicated brain functions arise from lots of different regions working together. Over the last several years, a branch ...

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