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Building Blocks: The Power of Proteins

By Lacy SchleyMay 9, 2017 5:00 PM
lab mouse shutterstock 556378909
(Credit: Shutterstock)


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New work in Nature Neuroscience offers some promise for understanding cocaine addiction. Researchers genetically engineered mice to produce cadherin, a protein involved in learning that helps strengthen the brain’s neural connections. The mice cranked out this protein in their reward circuits, a brain area that drives us to seek pleasure-inducing experiences and a key component in addiction. After introducing the cadherin-laden mice to cocaine multiple times, experts expected the rodents to crave the drug. Instead, the critters carried on without interest: The excess protein actually clogged their reward center circuitry, preventing the mice from getting hooked. The results point to the importance of biochemistry in addiction.

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