Microdosing Psychedelics as Treatment Could Increase Flexible Thinking

However, more work on just how these compounds rewire the brain will be necessary before they become viable treatments for humans.

By Paul Smaglik
Apr 22, 2025 9:00 PMApr 22, 2025 9:04 PM
Micro-dosing psychedelics
(Image Credit: Microgen/Shutterstock)

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One small dose of a psychedelic compound could help brains better adapt to changing circumstances, potentially improving treatments for those struggling with depression, PTSD, and neurodegenerative diseases, according to experiments conducted in mice. The results of the study were reported in the journal Psychedelics.

"What makes this discovery particularly significant is the sustained duration of cognitive benefits following just one psychedelic dose," Omar J. Ahmed, a psychology researcher at the University of Michigan and a co-author of the study, said in a press release. "We observed enhanced learning adaptability that persisted for weeks, suggesting these compounds may induce lasting and behaviorally meaningful neuroplasticity changes in the prefrontal cortex."

Measuring Cognitive Flexibility

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