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Metagenomic Sleuthing Treats Illness Like a Crime Scene

Discover how the Precision Diagnosis of Acute Infectious Diseases can transform infection testing with rapid results, identifying pathogens swiftly.

Charles Chiu in the lab with colleague Steve Miller.Credit: Elisabeth Fall/UCSF

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Pathogens move fast. You wake up one morning feeling ready to take on the world. On your way to work, you notice your throat’s a bit scratchy, your forehead a bit warm. By lunch you’ve got a pounding headache and it hurts to breathe. Co-workers agree, you’ve got whatever’s been going around. You end the day early, using the last of your strength to drag yourself to bed. Identifying the organism causing your misery can confound even trained physicians.

When tests fail to reveal what ails you, doctors are often left to make an educated guess, finding a cure through trial and error—a test for this, a test for that. It's a process that could take days, which is valuable lost time if the infection is severe. But Charles Chiu is developing a technique to reveal all the pathogens giving you grief—bacteria, fungi, viruses—in a single test.

Chiu believes they ...

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