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Keep Your Enemies Closer

Explore how smallpox eradication reshaped global health, and the debate over retaining the smallpox virus for vital research.

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If smallpox were still around today, no one would have parties to infect their children, like they do with chickenpox. Smallpox was no joke. The disease used to infect 50 million people a year, and as many as one in three infected people died. Most survivors were scarred with pockmarks, and some were left blind.

Of course, no one gets smallpox today. It's the only infectious disease of humans that we've successfully eradicated. The World Health Organization (WHO) began a serious vaccination campaign against smallpox in 1967 (though vaccination had been possible since around 1800), and in just a decade the disease had been wiped out. The last naturally occurring case of smallpox struck in 1977. Then laboratories set out to destroy their remaining stocks of the virus. By 1984, smallpox had been erased from everywhere on Earth except for two labs--the Centers for Disease Control in the United States, ...

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