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Why do you have blue eyes?

Discover how eye color inheritance is shaped by genetic variation, particularly the OCA2 gene and its blue eye allele.

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Well, you may not have blue eyes, but many people do. The post below suggests that there is still a lot of confusion on how eye color is inherited, but now in 2007 we are coming close to clearing up many issues. A paper which came out early this year, A Three-Single-Nucleotide Polymorphism Haplotype in Intron 1 of OCA2 Explains Most Human Eye-Color Variation (Open Access), suggests that about

3/4 of the eye color variation in Europeans (from pale blue to dark brown) can be explained by polymorphism around the OCA2 gene

. In other words, eye color comes close to being a monogenic Mendelian trait when it comes to inheritance, but not quite.

The diagram below is probably close to what you learned in high school:

Standard Model

Brown heterozygote parent

BlueBrown

Brown heterozygote parentBlue

Blue Blue (Blue phenotype)

Blue Brown (Brown phenotype)

Brown

Blue Brown (Brown phenotype)

Brown ...

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