Just Three Days on a High-Fat Diet Can Harm Your Brain

A new study finds that saturated fat can impair memory and cause brain inflammation in as little as three days.

By Stephanie Edwards
Mar 7, 2025 9:50 PMMar 21, 2025 4:43 PM
Blue and pink rendering of human brain
(Image Credit: Yurchanka Siarhei/Shutterstock)

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Although many of us like to indulge from time to time, it turns out that a high-fat diet can alter the brain after just a few days, even in healthy adults.

A study published in Immunity & Ageing reveals that eating a diet high in saturated fat for as short as three days can cause memory problems and brain inflammation in older adults. These results add to the already lengthy list of side effects of a fatty diet and suggest that it isn’t only overweight individuals who should be worried.

The Dangers of Saturated Fat

Researchers conducted their study using groups of rats. The rats were divided into these groups based on their age and were fed a high-fat diet for a period spanning three days to three months. Another group was fed a diet consisting of normal rat chow.

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