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Genetically Modifying Mosquitoes to Eliminate Disease

A remarkable scheme to alter the pest’s DNA could change the disease-carrying species for the better — or wipe them off the Earth.

The Anopheles mosquito, shown in an electron micrograph, spreads the malaria parasite.Credit: Thierry Berrod/Mona Lisa Production/Science Source

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Mosquitoes have pestered mankind for as long as we’ve had the wits to swat them. A mere annoyance in the temperate zones, mosquitoes in the tropics carry serious diseases, such as malaria and dengue fever. The former causes more than half a million deaths each year, mostly among children under 5, and the parasite responsible for malaria keeps growing more resistant to drugs. Meanwhile, the World Health Organization considers dengue fever the most important viral-borne disease in the world, with cases since World War II increasing thirtyfold — up to 50 million annual infections.

If you block the mosquitoes, the diseases’ vectors, you block their microbial payloads, but that’s easier said than done. Since DDT was taken off the market, mosquitoes in Africa, Asia and Latin America have evolved resistance to today’s less toxic chemical sprays. Biological methods, which pit other organisms (ranging from fungi to fish) against mosquitoes, have ...

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