Lou Genise, a compact man with a shorn head and Fu Manchu mustache, sat propped up on a mattress in a hospital room tucked away on the fifth floor of Harbor-UCLA Medical Center in Los Angeles. Wearing an eyeshade and listening to music through a headset, he was oblivious to the two psychiatrists sitting nearby, quietly monitoring his every move.
Worry and nausea had been the 37-year-old performance artist’s constant companions during his treatment for metastatic colon cancer that was diagnosed a year earlier. Yet the shroud of negativity lifted under the influence of psilocybin, the psychoactive ingredient in the hallucinogenic mushrooms used in sacred Native American rituals.
Early one morning last July, Genise had taken a little white capsule containing the psychedelic as part of a medically supervised study to test whether it could ease the mental anguish of people with terminal cancer. He had checked into the hospital the afternoon before, and Charles Grob, the UCLA psychiatrist who is conducting the study, reviewed with him the issues he wanted to confront. Genise said he had developed a Pavlovian aversion to hospitals after all he had been through and would get nauseated in anticipation of getting treatment. He was also having trouble accepting his separation from a former girlfriend, who had come to Los Angeles to care for him when he fell ill.
“I had dealt with the big, earth-shattering problems, but the day-to-day anxieties were the hard part,” Genise recalled five months later, sipping tea in his home in the L.A. neighborhood of Echo Park. “But following the session, I had two startling epiphanies. First, here I was in a hospital having a pleasurable experience, which immediately cured my anxieties. And it suddenly clicked in my head that I didn’t need to cling to my ex. It was a spectacular experience, because in a short time I was able to work through some serious issues on a very deep level.”
At a handful of sites across the country, after a four-decade hiatus, psychedelic research is undergoing a quiet renaissance, thanks to scientists like Charles Grob who are revisiting the powerful mind-altering drugs of the 1960s in hopes of making them part of our therapeutic arsenal. Hallucinogens such as psilocybin, MDMA (better known as Ecstasy), and the most controversial of them all, LSD, are being tested as treatments for maladies that modern medicine has done little to assuage, such as post-traumatic stress disorder, drug dependency, obsessive-compulsive disorder, cluster headaches, and the emotional suffering of people with a terminal illness.
