Blue eyes, why?

Gene Expression
By Razib Khan
Nov 20, 2006 11:31 PMNov 5, 2019 9:19 AM

Newsletter

Sign up for our email newsletter for the latest science news
 

I don't have time to comment in detail, but I thought I'd give readers a heads up, there is a preprint in The American Journal of Human Genetics which confirms that

a few SNPs on one locus is responsible for 3/4 of the variation between blue and brown eyes in white populations

. This locus, OCA2, is the third longest haplotype in the European genome from the HapMap sequence (the European HapMap data comes from Utah Mormons). The length of this haplotype is suggestive of recent strong positive selection within the European population (the further back in time and the weaker the selective event the more power recombination has to break up associations swept up during the sweep). OCA2 seems to have a relationship to skin color as well, though it is far weaker an effect (recall that we already know another locus in Europeans has an average effect of 25-38% of the variance between Europeans and Africans).

1 free article left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

1 free articleSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!

Subscribe

Already a subscriber?

Register or Log In

More From Discover
Stay Curious
Join
Our List

Sign up for our weekly science updates.

 
Subscribe
To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2025 LabX Media Group