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Being abnormal

Explore the genetic architecture of phenotypes and its role in understanding heritable quantitative traits and normal distribution of traits.

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In Unequal by nature: A geneticist's perspective on human differences, James F. Crow states:

Two populations may have a large overlap and differ only slightly in their means. Still, the most outstanding individuals will tend to come from the population with the higher mean.

This is a trivial observation. It is biologically relevant because heritable quantitative traits are to a great extent the raw material for evolution, and, they generally follow an approximate normal distribution. The reasoning is simple, many loci of small independent additive effects are a good approximation of the genetic architecture of many phenotypes, and this structure simulates, roughly, the independent random variables which result in a normal distribution because of the central limit theorem. Obviously two of the most important parameters in the normal distribution are the mean (which is also the mode & median in a perfectly ideal distribution) and variance around that mean. Unfortunately, ...

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