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African American reduced susceptibility to arthritis?

Discover how an African ancestry-specific allele in CTLA4 offers protection against rheumatoid arthritis in African Americans.

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A few years ago a brown friend of mine complained that there were all these diseases which non-white people were susceptible to at a higher rate (e.g., Type II Diabetes, hypertension, ateriosclerosis, etc.), perhaps the white race was really superior (or medical geneticists were entering into a conspiracy to prove that this was so). So with that, I point to a new PLoS Genetics paper, An African Ancestry-Specific Allele of CTLA4 Confers Protection against Rheumatoid Arthritis in African Americans:

Rheumatoid arthritis (RA) is a systemic autoimmune condition affecting the synovial membranes of diarthrodial joints. The etiology of RA is unclear but is thought to result from an environmental trigger in the context of genetic predisposition. We report that a single nucleotide polymorphism (SNP) (rs231778) in CTLA4, which encodes a negative regulator of T cell activation, is associated (p = 2.4×10−28) with protection from developing RA among African Americans. rs231778 is ...

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