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Understanding Umami

Discover the molecular mechanism of umami taste sensation and how glutamate enhances flavor perception with taste receptors.

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Imagine taking a bite of your favorite food. Is it sweet? Salty? Does it have a sour bite or a hint of bitterness? Maybe even a touch of savory umami? Every time we eat, our taste buds sample these five basic taste qualities. Taste receptors decorating the surface of each taste bud interact with specific molecules; the corresponding flavor sensation then gets sent to your brain. Umami receptors, for example, sense the molecule glutamate. When free glutamate in our food—either naturally occurring or from added MSG—interacts with an umami receptor, we taste a delicious savory flavor. Although glutamate is the primary source of umami flavor, certain molecules called nucleotides can enhance the umami sensation. Because nucleotides make up the genetic material (DNA and RNA) of all living things, nucleotides are ubiquitous in many of the foods we eat. Nucleotides themselves cannot activate umami taste receptors, but they can intensify the ...

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