How Is Antivenom Made?

Processing antibodies is a vital medical step that can save us from deadly snake bites. Find out how antivenom is made and why it is so hard to come by.

By Joshua Rapp Learn
Jun 13, 2023 4:00 PM
Fer-de-lance snake in Costa Rica
Fer-de-lance snake in Costa Rica. (Credit: Jim Cumming/Shutterstock)

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Clodomiro Picado, one of Costa Rica’s foremost scientists, conducted research on venomous snakes in Central America in the early-20th century and advocated for better products tailored to the types of snakes that lived in the area. 

The institute now named after him — the University of Costa Rica’s Clodomiro Picado Institute — is one of few in the world helping people bitten by snakes in Latin America and Africa. Before the institute was created, people in Costa Rica and surrounding countries often relied on antivenoms from as far away as Brazil or elsewhere.

The trouble is, antivenoms must be tailored to a particular species.

This is partly due to venoms naturally being tailored to the prey that lives in a particular area. In some cases, even the venoms of snakes within the same species differ substantially; antivenom based on the deadly fer-de-lance from Brazil, for example, may not be as effective in Central America.

Therefore, the first step in making the right antivenom is finding the right kind of snake.

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