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Resistance to an extinct virus makes us more vulnerable to HIV

Explore how immunity to viral infections makes humans vulnerable to HIV due to evolutionary trade-offs in TRIM5α protein.

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Immunity to viral infections sounds like a good thing, but it can come at a price. Millions of years ago, we evolved resistance to a virus that plagued other primates. Today, that virus is extinct, but our resistance to it may be making us more vulnerable to the present threat of HIV.

Many extinct viruses are not completely gone. Some members of a group called retroviruses insinuated themselves into our DNA and became a part of our genetic code. Indeed, a large proportion of the genomes of all primates consists of the embedded remnants of ancient viruses. Looking at these remnants is like genetic archaeology, and it can tell us about infections both past and present.

When retroviruses (such as HIV, right) infect a cell, they insert their own DNA into their host's genome, using it as a base of operations. From there, the virus can pop out again and ...

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