Ghosts in the E. coli machine

In today's New York Times I have an article about the quest to create a virtual organism—a sort of digital Frankenstein accurate down to every molecular detail. The creature that the scientists I write about want to reproduce is that familiar denizen of our gut, Escherichia coli. There are two things about this enterprise I find particularly delicious. One is that this little microbe is just too complex for today's computers to handle. For now scientists are just laying the groundwork for a day that might come in 10 or 20 years when they have enough processing power to handle E. coli. Another delicious fact is that despite fifty years of intense research, scientists don't know what a lot of E. coli's genes are for. All told, this black box swallows up about a quarter of its genome. The creationist frenzy of the past couple weeks gives these two facts ...