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Genetically-modified mosquitoes fight malaria by outcompeting normal ones

Discover how malaria-resistant mosquitoes are engineered to combat the Plasmodium parasite, potentially reducing malaria cases significantly.

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Fighting malaria with mosquitoes seems like an bizarrely ironic strategy but it's exactly what many scientists are trying to do. Malaria kills one to three million people every year, most of whom are children. Many strategies for controlling it naturally focus on ways of killing the mosquitoes that spread it, stopping them from biting humans, or getting rid of their breeding grounds.

But the mosquitoes themselves are not the real problem. They are merely carriers for the true cause of malaria - a parasite called Plasmodium. It suits neither mosquitoes nor humans to be infected with Plasmodium, and by helping them resist it, we may inadvertently help ourselves. With the power of modern genetics and molecular biology, scientists have produced strains of genetically engineered mosquitoes that cannot transmit the malarial parasite.

These 'GM-mosquitoes' carry a modified gene - a transgene - that produces chemicals which interfere with Plasmodium's development. Rather ...

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