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Did a gene enhancer humanise our thumbs?

Discover how the HACNS1 enhancer revolutionizes our understanding of human evolution and thumb development.

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The image on the right is both beautiful and exciting. Let me explain why. It's the paw of an embryonic mouse and a team of geneticists have inserted a fragment of human DNA into its cells. The fragment contains an "enhancer" element, a short span of DNA that switches other genes on and off; in this case, they put the enhancer in control of a gene whose activity creates a blue chemical.

This particular enhancer is called HACNS1. Throughout the course of animal evolution, its sequence has gone relatively unchanged in almost all back-boned animals, but it has evolved rapidly in the human genome since we split away from chimpanzees. So the blue patch in this image shows where this rapidly-evolved, human-specific piece of DNA is triggering genetic activity in the paw of a mouse. Figured out why it's exciting yet? It's in the bit that will eventually become a ...

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