The Brain: The Dark Matter of the Human Brain

Meet the forgotten 90 percent of your brain: glial cells, which outnumber your neurons ten to one. And no one really knows what they do.

By Carl Zimmer
Aug 19, 2009 5:00 AMNov 12, 2019 5:58 AM

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Some of the common words we use are frozen mistakes. The term influenza comes from the Italian word meaning “influence”—an allusion to the influence the stars were once believed to have on our health. European explorers searching for an alternate route to India ended up in the New World and uncomprehendingly dubbed its inhabitants indios, or Indians. Neuroscientists have a frozen mistake of their own, and it is a spectacular blunder. In the mid-1800s researchers discovered cells in the brain that are not like neurons (the presumed active players of the brain) and called them glia, the Greek word for “glue.” Even though the brain contains about a trillion glia—10 times as many as there are neurons—the assumption was that those cells were nothing more than a passive support system. Today we know the name could not be more wrong.

Glia, in fact, are busy multitaskers, guiding the brain’s development and sustaining it throughout our lives. Glia also listen carefully to their neighbors, and they speak in a chemical language of their own. Scientists do not yet understand that language, but experiments suggest that it is part of the neurological conversation that takes place as we learn and form new memories.

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