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Neurons transplanted into mouse spines reverse chronic pain

Not Exactly Rocket Science
By Ed Yong
May 24, 2012 8:10 PMNov 19, 2019 9:22 PM


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Several neural diseases, including chronic pain and epilepsy, involve a lack of restraint. That is, damage to nerves in the spine reduces the levels of a signalling chemical called GABA, which silences excitable neurons. The result: too much neural activity. There are drugs that can restore GABA, but they don't always work, they are only temporary and they have unwanted side effects like sedation. There is another option: transplant GABA-producing neurons directly into the spine. Scientists have now done this in mice, with successful results. I covered the story for The Scientist. Check it out. Photo by Nanny Snowflake

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