How Well Does Brain Structure Predict Behaviour?

Neuroskeptic iconNeuroskeptic
By Neuroskeptic
Sep 13, 2016 9:39 PMNov 20, 2019 12:56 AM

Newsletter

Sign up for our email newsletter for the latest science news
 

To what extent does brain structure correlate with different psychological traits? An interesting new paper from Massachusetts General Hospital researchers Mert R. Sabuncu and colleagues uses a new method to examine what the authors call the 'morphometricity' of various behaviours and mental disorders. Sabuncu et al. define morphometricity as "the proportion of phenotypic variation that can be explained by macroscopic brain morphology" - in other words, the degree to which people with similar brains tend to be similar in a particular behaviour. Morphometricity is somewhat analagous to the concept of heritability from genetics. Using FreeSurfer software and the statistical technique of linear mixed-effects (LME) modelling, the authors examined over 3,800 structural MRI scans, pooled from 9 studies. Sabuncu et al.'s analysis was based on calculating an anatomical similarity matrix (ASM) across the individual brains. The ASM represents the "global morphological resemblance between pairs of individuals in the sample". Essentially, the ASM represents how similar two individuals are in overall brain structure. Sabuncu then calculated the morphometricity of each trait by comparing the structural similarity to behavioural similarity. The results showed that Alzheimer's disease is almost perfectly morphometric, with an estimated value of 0.94–1.00 (where possible values range from 0 to 1). Schizophrenia was moderately morphometric (estimate 0.55), with autism coming in slightly lower at 0.38. Perhaps surprisingly, Parkinson's disease had a much lower morphometric value of just 0.20.

0 free articles left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

0 free articlesSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!

Subscribe

Already a subscriber?

Register or Log In

Stay Curious

Sign up for our weekly newsletter and unlock one more article for free.

 

View our Privacy Policy


Want more?
Keep reading for as low as $1.99!


Log In or Register

Already a subscriber?
Find my Subscription

More From Discover
Stay Curious
Join
Our List

Sign up for our weekly science updates.

 
Subscribe
To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2025 LabX Media Group