Register for an account

X

Enter your name and email address below.

Your email address is used to log in and will not be shared or sold. Read our privacy policy.

X

Website access code

Enter your access code into the form field below.

If you are a Zinio, Nook, Kindle, Apple, or Google Play subscriber, you can enter your website access code to gain subscriber access. Your website access code is located in the upper right corner of the Table of Contents page of your digital edition.

Mind

A Genomic Map of the Mouse Brain

Neuroskeptic iconNeuroskepticBy NeuroskepticFebruary 25, 2009 7:58 AM

Newsletter

Sign up for our email newsletter for the latest science news

Nature Neuroscience has a nice little report about a new resource that should prove useful for neuroscientists - an anatomic gene expression atlas of the adult mouse brain.

The atlas is freely available at http://mouse.brain-map.org/agea, courtesy of the Allen Foundation. It's a map of the entire adult mouse brain including data on the expression levels of 4,376 genes. You can click on a point in the brain and see which areas have a similar pattern of gene expression:

placeholder

The hotter the colour, the more correlated is the gene expression profile in that point vs. your selected region. This allows one to see the different regions of the brain defined not just anatomically, but genomically - fancy. Here I've clicked on a point in the cortex and this shows that other points in the cortex tend to have the same pattern of gene expression. That's hardly surprising, of course.

This is the kind of thing that will be invaluable for some neuroscientists, and not much use to most others, but it's a source of pretty pictures for everyone - and it's an example of the power of this kind of database. The genomic atlas is derived from the Allen Brain Atlas which allows you to see where in the brain any given gene is expressed. See also BrainMAP.org for a modest attempt to do the same thing for functional neuroimaging.

rb2_large_white.png

Lydia Ng, Amy Bernard, Chris Lau, Caroline C Overly, Hong-Wei Dong, Chihchau Kuan, Sayan Pathak, Susan M Sunkin, Chinh Dang, Jason W Bohland, Hemant Bokil, Partha P Mitra, Luis Puelles, John Hohmann, David J Anderson, Ed S Lein, Allan R Jones, Michael Hawrylycz (2009). An anatomic gene expression atlas of the adult mouse brain Nature Neuroscience, 12 (3), 356-362 DOI: 10.1038/nn.2281

    2 Free Articles Left

    Want it all? Get unlimited access when you subscribe.

    Subscribe

    Already a subscriber? Register or Log In

    Want unlimited access?

    Subscribe today and save 70%

    Subscribe

    Already a subscriber? Register or Log In