We have completed maintenance on DiscoverMagazine.com and action may be required on your account. Learn More

The G matrix, pleiotropy and quantitative traits

Gene Expression
By Razib Khan
Aug 23, 2008 12:28 AMNov 5, 2019 9:31 AM
gMatrix.jpg

Newsletter

Sign up for our email newsletter for the latest science news
 

My previous post, Weird lands of the tails, had some concepts implicit which I didn't elucidate in detail. For example, I assumed that the speed is a quantitative trait, and the many genes which control its variation have pleiotropic effects. That is, gene 1 has effect on phenotypes 1 through n. Gene 2 has effect on phenotype 1 through n. Speed may be just one of those phenotypes. More formally what I'm thinking about is a genetic variance-covariance matrix, or G matrix. If you keep the G matrix in mind I think it's kind of ludicrous to expect that speed was actually what was being selected for directly; but that's just me. If you want to know more about the G matrix, Comparative quantitative genetics: evolution of the G matrix is a good paper. Also check out The multivariate breeder's equation. There's a lot of talk about going beyond one-gene models and the retarded concepts which arise from them, but if people are serious about that, well, start looking into quantitative genetics and refine your mental models....

1 free article left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

1 free articleSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!

Subscribe

Already a subscriber?

Register or Log In

More From Discover
Recommendations From Our Store
Shop Now
Stay Curious
Join
Our List

Sign up for our weekly science updates.

 
Subscribe
To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2024 Kalmbach Media Co.