Tall, short, another locus

Gene Expression
By Razib Khan
Feb 13, 2009 8:55 AMNov 5, 2019 9:35 AM

Newsletter

Sign up for our email newsletter for the latest science news
 

Extended Haplotypes in the Growth Hormone Releasing Hormone Receptor Gene (GHRHR) Are Associated with Normal Variation in Height. Here's the important bit:

In the VB cohort the height of individuals carrying the associated haplotypes were 3.8 cm and 2.5 cm shorter for males and females, respectively, and in the NB cohort 2.1 cm and 1.2 cm shorter for males and females, respectively. After correcting for sex, age and population affinity, carrying or not carrying the negatively associated haplotype accounts for as much as 1.8% of the variation in height in our two populations (0.9% without adjustment).

"In our two populations" = two Swedish samples. The authors point out that if this pans out that this is a big effect, HMGA2 was a much smaller effect. Most of the height genes are much smaller effect than even HMGA. I'm not clear about the worldwide distribution of the haplotype that they have found here, though you should sniff around the SNPs with the HGDP Selection Browser. Main figure below.

1 free article left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

1 free articleSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!

Subscribe

Already a subscriber?

Register or Log In

More From Discover
Recommendations From Our Store
Stay Curious
Join
Our List

Sign up for our weekly science updates.

 
Subscribe
To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2024 LabX Media Group