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Stem Cells Taken From Adults and Reprogrammed May Be Rejected as Foreigners

Induced pluripotent stem cells may face rejection by the immune system, complicating their therapeutic potential.

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Mouse embyronic stem cells

What's the News: Reprogrammed stem cells---cells taken from an adult and turned back into stem cells

---can be rejected by the body, at least in mice, suggests a new Nature study

. Donated tissues and organs are often attacked by a patient's immune system, since reprogrammed stem cells can be made from a patient's own skin, researchers had hoped these cells offered a way to avoid such rejection by letting patients, in essence, donate tissue to themselves. But the new finding may be a significant setback to what is a promising line of treatment. How the Heck:

Researchers took embryonic stem cells and reprogrammed stem cells---called induced pluripotent stem cells, or iPS cells---from two strains of mice. The mice in each strain were genetically identical to each other, so that mice within a strain would essentially recognize each other's cells as their own.

As expected, mice ...

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