Stay Curious

SIGN UP FOR OUR WEEKLY NEWSLETTER AND UNLOCK ONE MORE ARTICLE FOR FREE.

Sign Up

VIEW OUR Privacy Policy


Discover Magazine Logo

WANT MORE? KEEP READING FOR AS LOW AS $1.99!

Subscribe

ALREADY A SUBSCRIBER?

FIND MY SUBSCRIPTION
Advertisement

One principal component to rule them all?

Explore human genetic diversity through PCA plots revealing relationships across global populations and the Out of Africa hypothesis.

Newsletter

Sign up for our email newsletter for the latest science news

Sign Up

Despite the reality that I've cautioned against taking PCA plots too literally as Truth, unvarnished and without any interpretive juice needed, papers which rely on them are almost magnetically attractive to me. They transform complex patterns of variation which you are not privy to via your gestalt psychology into a two or at most three dimensional representation which can you can grok immediately. That is why History and Geography of Genes was so engrossing. You recognize patterns which were otherwise unrecognizable. But how you interpret those patterns, that's a wholly different matter. And how those patterns arise is also not something one can ignore.

First, let's start with an easy case. To the left is a PCA plot with four populations. Nigerians, East Asians (Chinese + Japanese), Europeans (whites from Utah), and finally, African Americans. The x-axis is the first principal component of variation, and the y-axis the second. That ...

Stay Curious

JoinOur List

Sign up for our weekly science updates

View our Privacy Policy

SubscribeTo The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Subscribe
Advertisement

0 Free Articles