Register for an account


Enter your name and email address below.

Your email address is used to log in and will not be shared or sold. Read our privacy policy.


Website access code

Enter your access code into the form field below.

If you are a Zinio, Nook, Kindle, Apple, or Google Play subscriber, you can enter your website access code to gain subscriber access. Your website access code is located in the upper right corner of the Table of Contents page of your digital edition.


More dopamine (DRD2)

Gene ExpressionBy Razib KhanOctober 8, 2007 11:10 PM


Sign up for our email newsletter for the latest science news

Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning:

...Here, we show with genetic analyses that three independent dopaminergic^ mechanisms contribute to reward and avoidance learning in humans.^ A polymorphism in the DARPP-32 gene, associated with striatal^ dopamine function, predicted relatively better probabilistic^ reward learning. Conversely, the C957T polymorphism of the DRD2^ gene, associated with striatal D2 receptor function, predicted^ the degree to which participants learned to avoid choices that^ had been probabilistically associated with negative outcomes.^ The Val/Met polymorphism of the COMT gene, associated with prefrontal^ cortical dopamine function, predicted participants' ability^ to rapidly adapt behavior on a trial-to-trial basis. These findings^ support a neurocomputational dissociation between striatal and prefrontal dopaminergic mechanisms in reinforcement learning. Computational maximum likelihood analyses reveal independent gene effects on three reinforcement learning parameters that can explain the observed dissociations.

Related:Strange behavioral days?.

    3 Free Articles Left

    Want it all? Get unlimited access when you subscribe.


    Already a subscriber? Register or Log In

    Want unlimited access?

    Subscribe today and save 70%


    Already a subscriber? Register or Log In