We have completed maintenance on DiscoverMagazine.com and action may be required on your account. Learn More

Humans Have Hosted Tuberculosis Bacteria for at Least 9,000 Years

By Eliza Strickland
Oct 15, 2008 5:55 PMNov 5, 2019 6:39 AM


Sign up for our email newsletter for the latest science news

A genetic analysis of two 9,000-year-old human skeletons found off the coast of Israel reveal that the Neolithic people were infected with tuberculosis, making them the earliest known TB cases to be confirmed with genetic testing.

The bone discovery contradicts the long-held theory that human TB evolved from cattle strains around the time of animal domestication, says [study coauthor] Helen Donoghue.... Rather, high population densities could have made it easier for the disease to spread [New Scientist].

The skeletons of a mother and child were found amidst other artifacts of a Neolithic village, called Atlit-Yam, which is now covered by the Mediterranean Sea.

A roughly 25-year–old mother had apparently passed on the bacterial infection to her 1-year–old child, after which they both died and were buried together.... Salt water, sand and clay had covered the bodies, providing excellent conditions for bone preservation. Atlit-Yam was located within a coastal marshland before its immersion by the rising ocean [Science News].

Researchers noticed lesions on the bones that are characteristic of TB, and were able to extract DNA from the infection-damaged spots. Their analysis revealed genetic sequences that matched the DNA of Mycobacterium tuberculosis, the main bacterial strain of human TB. Says Donoghue:

"What is fascinating is that the infecting organism is definitely the human strain of tuberculosis, in contrast to the original theory that human TB evolved from bovine TB after animal domestication" [Telegraph].

While the Neolithic people of Atlit-Yam had domesticated cattle, researchers believed they hadn't yet begun dairying; the earlier theory assumed that TB spread from cows to humans through the consumption of infected milk. The findings, published in the journal PLoS ONE, push back the earliest confirmed date of human TB infection by 3,000 years; previously, the

oldest cases of human TB confirmed by ancient DNA include reports from Ancient Egypt (3500 B.C. to 2650 B.C.) and Neolithic Sweden (3200 B.C. to 2300 B.C.). There are also less reliable reports, based just on lesions on bones, dating back even earlier, including on a Homo erectus fossil from to 490,000 to 510,000 years ago in Turkey [LiveScience].

But in the absense of DNA evidence, some scientists are skeptical of the Homo erectus case. Related Content: 80beats: Controversial Study Links IMF Loans to a Rise in Tuberculosis Deaths The Loom: The Tubercular Hominid DISCOVER: Old Disease in the New World Image: Tel-Aviv University

1 free article left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

1 free articleSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!


Already a subscriber?

Register or Log In

More From Discover
Recommendations From Our Store
Shop Now
Stay Curious
Our List

Sign up for our weekly science updates.

To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2024 Kalmbach Media Co.