How Inflammation Can Cause Your Cells to Rush Life-and-Death Decisions

Cells exposed to an inflammatory signaling molecule are quicker to commit suicide—but speed can lead to mistakes.

By Nala Rogers
Jun 2, 2021 8:30 PMJun 9, 2021 8:12 PM
cells
(Credit: MattLphotography/Shutterstock)

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Inside Science) —  A molecule that triggers inflammation may send cells into a panic-like state, prompting them to rush decisions about when to commit suicide, according to new research. This could help quell viral infection by ensuring infected cells die before new viruses are released. But it appears to come at a cost: Uninfected cells sometimes kill themselves by mistake.

The new study, which was presented in March at a virtual meeting of the American Physical Society, focused on the effects of a signaling molecule called tumor necrosis factor alpha, or TNF. TNF is one of the messengers the immune system uses to ramp up inflammation.

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