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HIV and human variation

Explore how human genetic variation influences HIV infection and AIDS disease progression through chemokine gene cluster studies.

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There is a preprint in the website of The American Journal of Human Genetics titled "Genetic variation in the CCL18 - CCL3 - CCL4 chemokine gene cluster influences HIV-1 transmission and AIDS disease progression." The title is a mouthful, but the short of it is what we've known for a long time, that human genetic variatian responds differently to HIV infection (or the risk of infection). This is surely going to be important, not because the science is a priori killer, but because AIDS is a big public policy issue. Back in the 1990s some people were talking about HIV resulting in the extinction of the human race (OK, I'm mostly talking about my teachers), but real knowledge of evolution would have implied that this is ridiculous. Plagues and pandemics come and go, but the species always bounces back, and we are a numerous large mammal so operational immunity is ...

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