There are several papers and letters in Nature Genetics on the relationship between menarche, menopause, etc. and genetics. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche:
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 10-9), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 10-9), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
Loci at chromosomes 13, 19 and 20 influence age at natural menopause:
We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); ...
