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Health

Fine scale population substructure

Gene ExpressionBy Razib KhanMarch 6, 2009 1:58 AM

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Dienekes comments on the paper which showed genetic substructure among a set of Sardinian villages:

The take-home lesson is that wherever gene flow is impeded, no matter how geographically close, population differentiation can be recovered with dense autosomal genotype data. Really fine-scale ancestry analysis is now possible; I suspect that a combination of geography, religion, social class, language, and ethnic identification will be found to be predictive of a person's broad genetic makeup and vice versa. But, to discover these correlations, a large-scale collection of genotypic data is required.

The potential exploration of population structure mapping onto non-geographic variables is definitely going to be interesting.

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