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Health

Don't genetically profile yourself just yet...perhaps

Gene ExpressionBy Razib KhanJuly 7, 2010 7:52 PM

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Newsweek has a long piece up which reviews some major issues with the new study of centenarians that's been all over the media right now. Ed Yong already covered the paper, but I'm going to look at the details myself. Here's a update from the Newsweek post:

Within an hour of this story's publication, the Science study's authors released a statement which a BU spokeswoman described as appearing "because of your inquiry and a similar one from the New York Times concerning methodology used to test 2 of the 150 genetic variants." Here is what the statement says: "Since the publication of our study in Science, which was extensively peer-reviewed, a question has been raised about two elements of the findings. One has to do with two of the 150 genetic variants included in the prediction model, while the other is related to the criteria used to determine the significance of the individual variants. On the first concern, we have been made aware that there is a technical error in the lab test used on approximately 10% of the centenarian sample that involved the two of the 150 variants. Our preliminary analysis of this issue suggests that the apparent error would not effect the overall accuracy of the model. Because the issue has been raised since the publication of the paper, we are now closely re-examining the analysis. Another question that was raised concerns the criteria used to determine if an association between a genetic variant and exceptional longevity was statistically significant. We used standard criteria for the analysis, and we are confident that the appropriate threshold was used."

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