Dr. Daniel MacArthur has the must read post on the $48,000 whole-genome sequence. Dr. MacArthur notes that the price point isn't quite within reach for most of the population. Nevertheless, I do find it interesting that I asked Armand Leroi 4 years ago if he would forgo 1 month salary for a whole-genome sequence in 10 years. It looks like this will be possible much sooner than 2015.