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This 200-Acre, 'Humungous Fungus' May Help Unravel Why Cancer Genes Are Unstable

The humongous fungus clone from Michigan reveals genetic stability that may contrast with cancer genome instability.

The individual mushrooms on this 200-acre fungus only live a few weeks, but the organism itself has been around for some 2,500 years, scientists think.Credit: Johann Bruhn

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In the mid-’80s, scientists discovered a giant fungus growing in Michigan’s Upper Peninsula. Now, researchers have found the organism is at least 2,500 years old. And the secret to the mushroom’s longevity might be a genome that’s highly resistant to mutation, the team reports today in the journal Proceedings of the Royal Society B. The discovery could help researchers figure out why cancer genomes are so unstable.

In 1983, Johann Bruhn planted red pines in the forest. Within the next few years, the trees began to die. The trend continued for about 15 years. Bruhn, a forest health specialist at the University of Missouri in Columbia, traced the trees’ deaths to a species of honey mushroom dubbed Armillaria gallica, a parasitic fungus that preys on trees weakened by drought, insects and other fungal infections. Bruhn examined the fungus, taking it out of the forest to find out whether a unique ...

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