The Boltzmann Brain paradox is an argument against the idea that the universe around us, with its incredibly low-entropy early conditions and consequential arrow of time, is simply a statistical fluctuation within some eternal system that spends most of its time in thermal equilibrium. You can get a universe like ours that way, but you’re overwhelmingly more likely to get just a single galaxy, or a single planet, or even just a single brain — so the statistical-fluctuation idea seems to be ruled out by experiment. (With potentially profound consequences.)